In this issue of Structure, Conicella et al. (2016) present evidence that the low complexity C-terminal region of TDP-43 undergoes liquid-liquid phase separation. ALS-associated mutations alter this phase separation process, providing a possible mechanism for the pathology caused by these TDP-43 mutations. The work is strongly supportive of toxic loss of RNA processing function in ALS.
Chong, P. A., & Forman-Kay, J. D. (2016, September 6). A New Phase in ALS Research. Structure. Cell Press. https://doi.org/10.1016/j.str.2016.08.003