A new synthesis of cyclen (1,4,7,10-tetraazacyclododecane)

39Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Cyclen (I) was prepd. from triethylenetetraamine in two synthetic steps in 57% overall yield. The key step is the double reductive ring expansion of a tricyclic bisamidine to I with DIBALH (83% yield). The tricyclic bisamidine was prepd. in 69% yield by bis-S-alkylation of dithiooxamide with excess EtBr, followed by reaction with triethylenetetraamine. [on SciFinder (R)]

Cite

CITATION STYLE

APA

Weisman, G. R., & Reed, D. P. (1996). A new synthesis of cyclen (1,4,7,10-tetraazacyclododecane). Journal of Organic Chemistry, 61(15), 5186–5187. https://doi.org/10.1021/jo9606665

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free