Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces a conformational change, which can account for its temporally gated degradation. © 2011 Elsevier Inc.
Menet, J. S., & Rosbash, M. (2011, September 2). A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.08.015