Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation

291Citations
Citations of this article
327Readers
Mendeley users who have this article in their library.

Abstract

Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases. © 2008 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008, January 10). Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation. Cell Stem Cell. https://doi.org/10.1016/j.stem.2007.12.012

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free