A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

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Abstract

We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFR1 is sensitive to redox changes within living cells. This journal is © the Partner Organisations 2014.

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Yeow, J., Kaur, A., Anscomb, M. D., & New, E. J. (2014). A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes. Chemical Communications, 50(60), 8181–8184. https://doi.org/10.1039/c4cc03464c

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