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Novel mechanism for priming aromatic polyketide synthases

Chemistry and Biology
DOI: 10.1016/j.chembiol.2004.07.003
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Abstract

In this issue of Chemistry & Biology, a novel priming mechanism is proposed for aromatic polyketide biosynthesis, with an iterative type I polyketide synthase generating a starter unit primed for a type II polyketide synthase [6]. This novel priming system participates in hedamycin biosynthesis, a DNA alkylating agent.

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Salas, J. A. (2004). Novel mechanism for priming aromatic polyketide synthases. Chemistry and Biology. Elsevier Ltd. https://doi.org/10.1016/j.chembiol.2004.07.003

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