The NPM1 mutation type has no impact on survival in cytogenetically normal AML

15Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to clinical outcome. Our analyses were based on 349 NPM1-mutated AML patients treated in the AMLCG99 trial. Complete remission rates, overall survival and relapse-free survival were not significantly different between patients with NPM1 type A or rare type mutations. The NPM1 mutation type does not seem to play a role in risk stratification of cytogenetically normal AML. Copyright:

Cite

CITATION STYLE

APA

Pastore, F., Greif, P. A., Schneider, S., Ksienzyk, B., Mellert, G., Zellmeier, E., … Spiekermann, K. (2014). The NPM1 mutation type has no impact on survival in cytogenetically normal AML. PLoS ONE, 9(10). https://doi.org/10.1371/journal.pone.0109759

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free