Abstract
Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. 2013 Smith and Houghton; licensee BioMed Central Ltd.
Author supplied keywords
- *coughing/su [Surgery]
- *esophagus
- *laryngopharyngeal reflux
- airway dynamics
- airway pressure
- baclofen/dt [Drug Therapy]
- bronchospasm
- chronic cough/dt [Drug Therapy]
- dextromethorphan/dt [Drug Therapy]
- dysphagia/co [Complication]
- esophagus motility
- gabapentin/dt [Drug Therapy]
- gastroesophageal reflux
- glutamate receptor antagonist/dt [Drug Therapy]
- human
- ketamine
- lesogaberan/ct [Clinical Trial]
- lesogaberan/dt [Drug Therapy]
- lower esophagus sphincter
- lung aspiration
- lung lavage
- morphine/dt [Drug Therapy]
- pepsin A/dt [Drug Therapy]
- peristalsis
- proton pump inhibitor/dt [Drug Therapy]
- provocation
- review
- stomach fundoplication
- treatment outcome
- vagus reflex
Cite
CITATION STYLE
J.A., S., & L.A., H. (2013). The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes. Cough, 9(1), 1–9. Retrieved from http://www.coughjournal.com/content/9/1/12%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed11&NEWS=N&AN=2013579943
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