Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. 2013 Smith and Houghton; licensee BioMed Central Ltd.
J.A., S., & L.A., H. (2013). The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes. Cough. J.A. Smith, Respiratory and Allergy Centre, The University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom. E-mail: email@example.com: BioMed Central Ltd. (Floor 6, 236 Gray’s Inn Road, London WC1X 8HB, United Kingdom). Retrieved from http://www.coughjournal.com/content/9/1/12