Oleanolic acid enhances insulin secretion in pancreatic β-cells

Citations of this article
Mendeley users who have this article in their library.


We investigated the effect of oleanolic acid, a plant-derived triterpenoid, on insulin secretion and content in pancreatic β-cells and rat islets. Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in INS-1 832/13 cells and enhanced acute glucose-stimulated insulin secretion in isolated rat islets. In the cell line the effects of oleanolic acid on insulin secretion were comparable to that of the sulfonylurea tolbutamide at basal glucose levels and with the incretin mimetic Exendin-4 under glucose-stimulated conditions, yet neither Ca2+ nor cAMP rose in response to oleanolic acid. Chronic treatment with oleanolic acid increased total cellular insulin protein and mRNA levels. These effects may contribute to the anti-diabetic properties of this natural product. © 2008 Federation of European Biochemical Societies.




Teodoro, T., Zhang, L., Alexander, T., Yue, J., Vranic, M., & Volchuk, A. (2008). Oleanolic acid enhances insulin secretion in pancreatic β-cells. FEBS Letters, 582(9), 1375–1380. https://doi.org/10.1016/j.febslet.2008.03.026

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free