Omega Conus geographus toxin: A peptide that blocks calcium channels

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Abstract

We previously reported that omega Conus geographus toxin (ωCgTX), blocks evoked-release of transmitter at synapses in frog and attenuates the Ca2+ component of the action potential of chick dorsal root ganglion neurons. We report here voltage-clamp experiments on cultured chick dorsal root ganglion neurons which demonstrate that ωCgTX produces a persistent block of voltage-gated Ca2+ currents. Thus, we conclude that ωCgTX inhibits synaptic transmission by blocking Ca2+ channels in the presynaptic nerve terminal. The toxin had no effect on K+ currents; however, in some but not all neurons, ωCgTX reduced Na+ currents by 10-25%. These findings suggest that ωCgTX should be useful as a probe to examine synaptic Ca2+ channels. © 1987.

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Feldman, D. H., Olivera, B. M., & Yoshikami, D. (1987). Omega Conus geographus toxin: A peptide that blocks calcium channels. FEBS Letters, 214(2), 295–300. https://doi.org/10.1016/0014-5793(87)80073-X

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