A new one-pot and efficient three-component condensation of aldehyde, ketones, and amines in the presence of MgO/ZrO 2 as an inexpensive and effective catalyst for the synthesis of beta-amino carbonyl compounds by Mannich reaction is described. The present methodology offers several advantages, such as good yields, Short reaction times and a recyclable catalyst with a very easy work up.
M., N. D., M., A. D., & B., G. M. (2014). One-pot Preparation of ?–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst. International Journal of Chemistry, 2(2). https://doi.org/10.5539/ijc.v2n2p98