Following myomectomy the rate of fertility is restored and pregnancy may be attempted with a good outcome. In the present study a 3 month treatment with OCs in a group of women after a myomectomy was evaluated. The drug compliance and side effects, the benefits of OC in order to reduce symptoms, to increase post-surgical hemoglobin levels and to avoid an early pregnancy after myomectomy were analyzed. A group of women () each with myoma 5 cm was recruited: they presented menorrhagia, pelvic pain, dyspareunia and dysmenorrhae. After laparotomic myomectomy the women were divided into 3 groups. Group 1: women () treated with pill A (15 mcg of ethynilestradiol + 60 mcg of gestodene); group 2: women () treated with pill B (20 mcg of ethynilestradiol + 100 mcg of levonorgestrel); group 3: women () treated with a placebo (oral calcium). After three months from myomectomy and treatment patients in each group reported a reduced menorrhagia, dismenorrhea and pelvic pain. Serum haemoglobin levels increased in all women (). No pregnancy occurred in any group and the compliance was good. A post surgery treatment by using oral contraceptives guarentees pregnancy prevention, associated with reduction of pain, and improvement of haematologic conditions.
Petraglia, F., Luisi, S., Ciani, V., Gabbanini, M., Sollazzi, S., Torricelli, M., & Calonaci, F. (2009). Oral contraceptives after myomectomy: A short term trial. International Journal of Endocrinology, 2009. https://doi.org/10.1155/2009/476897