Oral repeated-dose systemic and reproductive toxicity of 6:2 FLUOROTELOMER alcohol in mice

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Abstract

6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential systemic repeated-dose and reproductive toxicity in mice. 6:2 FTOH was administered by oral gavage to CD-1 mice as a suspension in 0.5% aqueous methylcellulose with 0.1% Tween-80 at dosages of 1, 5, 25, or 100. mg/kg/day. The no-observed-adverse-effect level (NOAEL) for systemic toxicity was 25. mg/kg/day (males) and 5. mg/kg/day (females), based on effects at higher doses on mortality, clinical observations, body weight, nutritional parameters, hematology (red and white blood cell), clinical chemistry (liver-related), liver weights, and histopathology (liver, teeth, reproductive tract, and mammary gland). However, 6:2 FTOH was not a selective reproductive toxicant. The NOAEL for reproductive toxicity was >100. mg/kg/day; no effects on reproductive outcome were observed at any dosage. The NOAEL for viability and growth of the offspring was 25. mg/kg/day, based on clinical signs of delayed maturation in pups, and reductions in pup survival and pup body weight during lactation at 100. mg/kg/day. While the severity of the effects was generally greater in mice than previously reported in CD rats, the overall NOAELs were identical in both species, 5. mg/kg/day for systemic toxicity and 25. mg/kg/day for offspring viability/growth. 6:2 FTOH was not a selective reproductive toxicant in either species; no effects on reproductive outcome occurred at any dose level, and any effects observed in offspring occurred at dose levels that induced mortality and severe toxicity in maternal animals.

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Mukerji, P., Rae, J. C., Buck, R. C., & O’Connor, J. C. (2015). Oral repeated-dose systemic and reproductive toxicity of 6:2 FLUOROTELOMER alcohol in mice. Toxicology Reports, 2, 130–143. https://doi.org/10.1016/j.toxrep.2014.12.002

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