Organization and expression of the chum salmon insulin-like growth factor II gene

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Abstract

IGF-II plays an important role in growth and development of vertebrates. In the present study, the characterization of the first fish IGF-II gene, chum salmon IGF-II, is described. The sIGF-II gene consists of four exons, spanning a region of 9 kbp, that encode the 214 aa IGF-II precursor. While the amino acid sequences of fully processed IGF-II of salmon and mammalian species are very similar, the prepro-peptide sequence deviates extensively in the signal- and E-peptide domains. The transcription initiation site of the sIGF-II gene was localized within a 30 nt region employing RT-PCR. Using sIGF-II promoter-luciferase constructs it was demonstrated that the sIGF-II gene has a relatively strong promoter that contains tissue-specific regulatory elements.

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Palamarchuk, A. Y., Holthuizen, P. E., Müller, W. E. G., Sussenbach, J. S., & Kavsan, V. M. (1997). Organization and expression of the chum salmon insulin-like growth factor II gene. FEBS Letters, 416(3), 344–348. https://doi.org/10.1016/S0014-5793(97)01217-9

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