An Orwellian Discourse on the Meaning and Measurement of Noninferiority

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Abstract

The customary interpretation of active-controlled noninferiority trials is founded on a number of unverifiable assumptions. These assumptions can be circumvented, and the semantic and statistic interpretation of the trials placed on a more rational foundation, if treatment comparisons are analyzed from a Bayesian perspective. In conclusion, the resultant probabilistic measures thereby render the meaning of noninferiority more transparent and clinically relevant. © 2007 Elsevier Inc. All rights reserved.

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Diamond, G. A., & Kaul, S. (2007, January 15). An Orwellian Discourse on the Meaning and Measurement of Noninferiority. American Journal of Cardiology. Elsevier Inc. https://doi.org/10.1016/j.amjcard.2006.07.090

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