The HtrA protein of Escherichia coli is a heat-shock inducible periplasmic protease, essential for bacterial survival at high temperatures. Expression of htrA gene depends on the alternative factor σE and on the two-component regulatory system Cpx. These regulators systems respond, among others factors, to overproduction of misfolded proteins in the periplasm or to high level synthesis of various extracytoplasmic proteins. We describe in this report the osmoregulation of the expression of htrA gene. Low osmolarity conditions result in htrA repression. We report, as well, the role of the nucleoid associated proteins H-NS and Hha in the repression of htrA expression at low osmolarity. © 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
Forns, N., Juárez, A., & Madrid, C. (2005). Osmoregulation of the HtrA (DegP) protease of Escherichia coli: An Hha-H-NS complex represses HtrA expression at low osmolarity. FEMS Microbiology Letters, 251(1), 75–80. https://doi.org/10.1016/j.femsle.2005.07.027