Outcome of severe obsessive-compulsive disorder with schizotypal features: A pilot study

  • L.-C. H
  • T.-J. H
  • G.-H. H
  • et al.
ISSN: 0929-6646
Citations of this article
Mendeley users who have this article in their library.


Background/Purpose: Long-term outcome of patients with severe obsessive-compulsive disorder (OCD) and schizotypal features has been rarely studied. We investigated this issue in this retrospective pilot study. Methods: Twenty-two patients with severe OCD and schizotypal features were identified by chart review. Another 22 OCD patients without schizotypal features (OCD-NS) served as the comparison group. Those with schizotypal features must not fulfill a diagnosis of schizophrenia or schizotypal disorder. After an average follow-up of 6.6 years, each patient received a re-diagnosis clinical interview. Relevant demographic and clinical data were collected. Patients with schizotypal features were classified into two groups after rediagnosis: those with schizophrenia or schizotypal disorder (OCD-SS group, n = 9) and those with only schizotypal traits (OCD-ST group, n = 13) that did not fulfill a well-formed schizophrenia-spectrum disorder. Demographic data, family history, clinical symptoms, and OCD course were compared among the three patient groups. Results: Compared with the OCD-NS group, the OCD-SS group was significantly less educated, less likely to be married or female, and had earlier onset of illness and poorer OCD course (p < 0.05). There was no significant difference in any demographic and clinical variables between the OCD-SS and OCD-ST groups except that the OCD-ST group had a significantly better OCD course (p < 0.01). Conclusion: The findings suggest that a substantial proportion of the patients with severe OCD and schizotypal features evolve into schizophrenia spectrum disorder and are associated with a poor long-term outcome, whereas the OCD-NS group might stay with limited manifestations of schizotypal features and have a better outcome. &#xa9; 2011 Elsevier & Formosan Medical Association.




L.-C., H., T.-J., H., G.-H., H., & H.-G., H. (2011). Outcome of severe obsessive-compulsive disorder with schizotypal features: A pilot study. Journal of the Formosan Medical Association, 110(2), 85–92. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L361703700

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free