The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration

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Abstract

Bone morphogenetic proteins (BMPs) have been shown to participate in the patterning and specification of several tissues and organs during development and to regulate cell growth, differentiation and migration in different cell types. BMP-mediated cell migration requires activation of the small GTPase Cdc42 and LIMK1 activities. In our earlier report we showed that activation of LIMK1 also requires the activation of PAKs through Cdc42 and PI3K. However, the requirement of additional signaling is not clearly known.

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Gamell, C., Susperregui, A. G., Bernard, O., Rosa, J. L., & Ventura, F. (2011). The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration. PLoS ONE, 6(1). https://doi.org/10.1371/journal.pone.0016477

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