In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise. © 2006 Elsevier Inc. All rights reserved.
Kruse, J. P., & Gu, W. (2006, July). p53 aerobics: The major tumor suppressor fuels your workout. Cell Metabolism. https://doi.org/10.1016/j.cmet.2006.06.004