Gong et al. report that in contrast to promoting apoptosis in hyperthermia conditions, both zebrafish and human tumor repressor p53 protect cells from death by preventing a hyperreactive heat shock response at 40°C, the heatstroke threshold temperature (HTT). They may provide a strategy for individualized therapy for p53-deficient cancers.
Gong, L., Zhang, Q., Pan, X., Chen, S., Yang, L., Liu, B., … Chen, J. (2019). p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Reports, 29(11), 3693-3707.e5. https://doi.org/10.1016/j.celrep.2019.11.032