Paneth cells in intestinal homeostasis and tissue injury

95Citations
Citations of this article
165Readers
Mendeley users who have this article in their library.

Abstract

Adult stem cell niches are often co-inhabited by cycling and quiescent stem cells. In the intestine, lineage tracing has identified Lgr5+ cells as frequently cycling stem cells, whereas Bmi1+, mTert+, Hopx+ and Lrig1+ cells appear to be more quiescent. Here, we have applied a non-mutagenic and cell cycle independent approach to isolate and characterize small intestinal label-retaining cells (LRCs) persisting in the lower third of the crypt of Lieberkühn for up to 100 days. LRCs do not express markers of proliferation and of enterocyte, goblet or enteroendocrine differentiation, but are positive for Paneth cell markers. While during homeostasis, LR/Paneth cells appear to play a supportive role for Lgr5+ stem cells as previously shown, upon tissue injury they switch to a proliferating state and in the process activate Bmi1 expression while silencing Paneth-specific genes. Hence, they are likely to contribute to the regenerative process following tissue insults such as chronic inflammation. © 2012 Roth et al.

Cite

CITATION STYLE

APA

Roth, S., Franken, P., Sacchetti, A., Kremer, A., Anderson, K., Sansom, O., & Fodde, R. (2012). Paneth cells in intestinal homeostasis and tissue injury. PLoS ONE, 7(6). https://doi.org/10.1371/journal.pone.0038965

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free