Panton-valentine leukocidin in community and hospital-acquired staphylococcus aureus strains

Citations of this article
Mendeley users who have this article in their library.


Staphylococcus aureus causes serious hospital-acquired (HA) and community-acquired (CA) infections. Skin and soft-tissue infections especially are sometimes caused by strains harbouring Panton-Valentine leukocidin (PVL). PVL belongs to a family of bi-component leukocidal toxins produced by staphylococci. It is a pore-forming toxin encoded by lukF-PV and lukS-PV. A total of 70 S. aureus strains: 38 (54%) methicillin-resistant (MRSA) and 32 (46%) methicillin-susceptible (MSSA), were isolated from patients admitted to Dicle University Hospital (Turkey). Identification of S. aureus and antibiotics-susceptibility testing were performed with PHOENIX 100. PVL genes and mecA genes were detected by polymerase chain reaction. Of the 70 studied strains, 36 ones (51%) were community acquired and 34 ones (49%) were hospital acquired . A total of 38 (54%) strains were positive for mecA (mecA(+)), of which 32 ones (84%) were HA. Of the mecA(-) strains, 30 (94%) were CA. Of the 70 studied strains, 12 (17%) strains were PVL(+): 8 (22%) of the 36 CA strains and 4 (12%) of the 34 HA strains. Of the 12 PVL(+) strains, 4 strains were mecA(+). The PVL positivity rate was 25% in MSSA, whereas 10.5% in MRSA. Of the overall PVL(+) strains, seven strains were obtained from wounds; four ones from skin abscess; and one from blood culture. Taken together, the obtained results showed a substantial level of PVL genes in the studied region. Although PVL is known as a common virulence factor of CA MRSA, HA MRSA isolates in our study showed a considerable rate of PVL positivity.




Ozekinci, T., Dal, T., Yanı, K., Ozcan, N., Can, S., Tekin, A., … Kandemir, I. (2014). Panton-valentine leukocidin in community and hospital-acquired staphylococcus aureus strains. Biotechnology and Biotechnological Equipment, 28(6), 1089–1094.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free