Paraphilic Sexual Offenders Do Not Differ From Control Subjects With Respect to Dopamine- and Serotonin-Related Genetic Polymorphisms

  • A. J
  • A. K
  • M. B
  • et al.
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Abstract

Introduction: Rape and pedophilic child molestation are the most commonly convicted sexual offenses in Poland. Recent studies have suggested a possible genetic contribution toward pathologic sexual interests and behaviors. Aim: To analyze and compare functional polymorphisms of genes associated with the activity of the serotonin and dopamine systems in a group of paraphilic sexual offenders and control subjects. Methods: The study sample (n = 97) consisted of two groups: paraphilic sexual offenders (65 pedophilic child molesters and 32 rapists) and controls (n = 76). Genetic polymorphisms previously associated with behavioral control, addictive behaviors, and sexual functions were chosen for analyses. Specifically, functional polymorphisms in dopamine receptors genes (DRD1, DRD2, DRD4), catechol-O-methyltransferase gene (COMT), dopamine transporter gene (DAT), serotonin transporter gene (SLC6A4), serotonin type 2A receptor gene (5HTR2A), tryptophan hydroxylase 2 gene (TPH2), monoamine oxidase A gene (MAOA), and brain-derived neurotrophic factor gene (BDNF) were analyzed. Main Outcome Measures: An association between a history of sexual offense and the distribution of genotypes and alleles in the analyzed polymorphisms. Results: Our results found no association between a history of sexual offense and the distribution of genotypes or alleles in the analyzed polymorphisms. Conclusion: Although these results are limited by the small sample and are exploratory, they highlight a novel approach to sample selection in a population that is difficult to access and study. Future research should include larger samples and other relevant polymorphisms to advance this field of study., Copyright © 2016 International Society for Sexual Medicine.

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APA

A., J., A., K., M., B., M., K., A., K., A., L., … K., B. (2016). Paraphilic Sexual Offenders Do Not Differ From Control Subjects With Respect to Dopamine- and Serotonin-Related Genetic Polymorphisms. Journal of Sexual Medicine. A. Krasowska, Department of Psychiatry, Medical University of Warsaw, 27 Nowowiejska Street, Warsaw 00-665, Poland: Elsevier B.V. (E-mail: customerservices@oxonblackwellpublishing.com). Retrieved from http://www.journals.elsevier.com/the-journal-of-sexual-medicine

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