Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

  • K. F
  • J. T
  • Y. S
  • et al.
N/ACitations
Citations of this article
1Readers
Mendeley users who have this article in their library.

Abstract

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

Cite

CITATION STYLE

APA

K., F., J., T., Y., S.-M., Y., S., T., S., & K., S. (2015). Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation. Journal of Pharmacological Sciences. K. Sato, Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan: Japanese Pharmacological Society. Retrieved from http://www.jstage.jst.go.jp/browse/

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free