The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity. © 2010 Elsevier Inc.
Krishnakumar, R., & Kraus, W. L. (2010, July). The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.06.017