Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.
Kelley, L. A., & Sternberg, M. J. E. (2015). Partial protein domains: Evolutionary insights and bioinformatics challenges. Genome Biology, 16(1). https://doi.org/10.1186/s13059-015-0663-8