Partial response to anakinra in life-threatening Henoch-Schönlein purpura: Case report

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Abstract

ABSTRACT: Henoch-Schönlein purpura is one of the most common forms of systemic vasculitis of childhood. We report the response to anakinra, the interleukin-1 receptor antagonist, in a 9 year old girl without prior medical problems who developed life-threatening Henoch-Schönlein vasculitis that produced renal failure, pulmonary hemorrhage and vasculitis of the brain. Her response supports the theory that interleukin-1 may be an important mediator in this disease. Further study of interleukin-1 antagonists in severe Henoch-Schönlein purpura may be warranted.

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Boyer, E. M., Turman, M., & O’Neil, K. M. (2011). Partial response to anakinra in life-threatening Henoch-Schönlein purpura: Case report. Pediatric Rheumatology, 9. https://doi.org/10.1186/1546-0096-9-21

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