The PathLinker app: Connect the dots in protein interaction networks

  • Gil D
  • Law J
  • Murali T
N/ACitations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

PathLinker is a graph-theoretic algorithm for reconstructing the interactions in a signaling pathway of interest. It efficiently computes multiple short paths within a background protein interaction network from the receptors to transcription factors (TFs) in a pathway. We originally developed PathLinker to complement manual curation of signaling pathways, which is slow and painstaking. The method can be used in general to connect any set of sources to any set of targets in an interaction network. The app presented here makes the PathLinker functionality available to Cytoscape users. We present an example where we used PathLinker to compute and analyze the network of interactions connecting proteins that are perturbed by the drug lovastatin.

Cite

CITATION STYLE

APA

Gil, D. P., Law, J. N., & Murali, T. M. (2017). The PathLinker app: Connect the dots in protein interaction networks. F1000Research, 6, 58. https://doi.org/10.12688/f1000research.9909.1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free