A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

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Abstract

Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.

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APA

Broin, P. O., Hayde, N., Bao, Y., Ye, B., Calder, R. B., de Boccardo, G., … Golden, A. (2014). A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies. Genomics Data, 2, 357–360. https://doi.org/10.1016/j.gdata.2014.10.005

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