The pathological splicing mutation c.6792C > G in NF1 exon 37 causes a change of tenancy between antagonistic splicing factors

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Abstract

We have previously identified an ESE in NF1 exon 37 whose disruption by the pathological mutation c.6792C > G caused aberrant splicing. We now investigate the RNA-protein complexes affected by the c.6792C > G mutation observing that this concurrently decreases the affinity for the positive splicing factor YB-1 and increases the affinity for the negative splicing factors, hnRNPA1, hnRNPA2 and a new player in these type of complexes, DAZAP1. Our findings highlight the complexity of the interplay between positive and negative factors in the exon inclusion/skipping outcome. Furthermore, our observations stress the role of a wide genomic context in NF1 exon 37 definition. © 2008 Federation of European Biochemical Societies.

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Skoko, N., Baralle, M., Buratti, E., & Baralle, F. E. (2008). The pathological splicing mutation c.6792C > G in NF1 exon 37 causes a change of tenancy between antagonistic splicing factors. FEBS Letters, 582(15), 2231–2236. https://doi.org/10.1016/j.febslet.2008.05.018

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