Pathophysiology of mitochondrial volume homeostasis: Potassium transport and permeability transition

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Abstract

Regulation of mitochondrial volume is a key issue in cellular pathophysiology. Mitochondrial volume and shape changes can occur following regulated fission-fusion events, which are modulated by a complex network of cytosolic and mitochondrial proteins; and through regulation of ion transport across the inner membrane. In this review we will cover mitochondrial volume homeostasis that depends on (i) monovalent cation transport across the inner membrane, a regulated process that couples electrophoretic K+ influx on K+ channels to K+ extrusion through the K+-H+ exchanger; (ii) the permeability transition, a loss of inner membrane permeability that may be instrumental in triggering cell death. Specific emphasis will be placed on molecular advances on the nature of the transport protein(s) involved, and/or on diseases that depend on mitochondrial volume dysregulation. © 2008 Elsevier B.V. All rights reserved.

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Nowikovsky, K., Schweyen, R. J., & Bernardi, P. (2009, May). Pathophysiology of mitochondrial volume homeostasis: Potassium transport and permeability transition. Biochimica et Biophysica Acta - Bioenergetics. https://doi.org/10.1016/j.bbabio.2008.10.006

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