Pellino enhances innate immunity in Drosophila

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The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-κB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila. © 2010 Elsevier Ireland Ltd.

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Haghayeghi, A., Sarac, A., Czerniecki, S., Grosshans, J., & Schöck, F. (2010). Pellino enhances innate immunity in Drosophila. Mechanisms of Development, 127(5–6), 301–307.

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