Peripheral neuropathy in cystic fibrosis: A prevalence study

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Background: Information on peripheral neuropathy in children with cystic fibrosis is scanty. The etiology can be multifactorial (micronutrient deficiency, chronic hypoxia, impaired glucose tolerance, immunological, vasculopathic, critical illness). Methods: Forty five cystic fibrosis children aged 1-18. years on vitamin E supplementation for at least 6. months underwent detailed neurological examination, serum vitamin E, vitamin B12, folate, copper levels and detailed nerve conduction studies. Results: The mean age of the study population was 8.35. years (± 4.9 years) with 62.2% being males. Overall 22 out of 45 (48.88%,CI: 33.7-64.2) had electrophysiological evidence of peripheral neuropathy which was predominantly axonal (86.4%), sensory (50%), and polyneuropathy (95.45%). There was no significant association between status of serum micronutrients and electrophysiological evidence of peripheral neuropathy. Conclusion: Patients with cystic fibrosis have electrophysiological evidence of peripheral neuropathy (predominantly axonal, sensory and polyneuropathy). There is significant association of higher chronological age with occurrence of peripheral neuropathy. © 2013 European Cystic Fibrosis Society.




Chakrabarty, B., Kabra, S. K., Gulati, S., Toteja, G. S., Lodha, R., Kabra, M., … Srivastava, A. (2013). Peripheral neuropathy in cystic fibrosis: A prevalence study. Journal of Cystic Fibrosis, 12(6), 754–760.

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