Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts

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Abstract

The reduced bone mineral density (BMD) observed in osteoporosis results, in part, from reduced activity of bone-forming osteoblasts. We examined the effect of peroxisome proliferator-activated receptor (PPAR) activators on MC3T3-E1 preosteoblast maturation. Activators of PPARα, δ and γ induced alkaline phosphatase activity, matrix calcification and the expression of osteoblast genes as determined by reverse transcriptase-polymerase chain reaction. However, at relatively high concentrations of the specific PPARγ ligands, ciglitazone and troglitazone, maturation was inhibited. PPARα, δ and γ1 were expressed in MC3T3-E1 cells. PPARγ1 mRNA and protein levels were induced early during osteoblastic maturation. We speculate that endogenous and pharmacological PPAR activators may affect BMD by modulating osteoblastic maturation. Copyright (C) 2000 Federation of European Biochemical Societies.

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Jackson, S. M., & Demer, L. L. (2000). Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts. FEBS Letters, 471(1), 119–124. https://doi.org/10.1016/S0014-5793(00)01372-7

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