Pet-guided surgery - high correlation between positron emission tomography with 11C-5-Hydroxytryptophane (5-HTP) and surgical findings in abdominal neuroendocrine tumours

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Abstract

Positron emission tomography (PET) with 11C-labeled 5-hydroxytryptophane (5-HTP) is a sensitive technique to visualize neuroendocrine tumours (NETs), due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA) and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET patients underwent 11C-5-HTP-PET and morphological imaging by CT within 12 weeks prior to surgery. Surgical, histopathological and 5-HTP PET findings were correlated. 11C-5-HTP-PET corresponded to the surgical findings in 31 cases, was false negative in six, and true negative in one case resulting in 83.8% sensitivity and 100% specificity. Positive predicted value was 100%. In 11 patients 11C-5-HTP-PET was the only imaging method applied to localize the tumour. Thus, we could demonstrate that functional imaging by 11C-5-HTP-PET in many cases adds vital preoperative diagnostic information and in more than every fourth patient was the only imaging method that will guide the surgeon in finding the NET-lesion. Although the present results demonstrates that 11C-5-HTP may be used as an universal NET tracer, the sensitivity to visualize benign insulinomas and non functioning pancreatic NETs was lower. © 2012 by the authors; licensee MDPI, Basel, Switzerland.

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Örlefors, H., Sundin, A., Eriksson, B., Skogseid, B., Öberg, K., Åkerström, G., & Hellman, P. (2012). Pet-guided surgery - high correlation between positron emission tomography with 11C-5-Hydroxytryptophane (5-HTP) and surgical findings in abdominal neuroendocrine tumours. Cancers, 4(1), 100–112. https://doi.org/10.3390/cancers4010100

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