A phase I, first-in-human study of AMG 780, an angiopoietin-1 and-2 inhibitor, in patients with advanced solid tumors

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Abstract

Purpose: To assess the toxicity, pharmacokinetics, tumor vascular response, tumor response, and pharmacodynamics of AMG 780, a monoclonal antibody designed to inhibit the interaction between angiopoietin-1 and-2 and the Tie2 receptor. Experimental Design: This was a phase 1 dose-escalation study of patients with advanced solid tumors refractory to standard treatment without previous antiangiogenic treatment. AMG 780 was administered by intravenous infusion every 2 weeks (Q2W) in doses from 0.1 to 30 mg/kg. The primary endpoints were incidences of dose-limiting toxicity (DLT) and adverse events (AEs), and pharmacokinetics. Secondary endpoints included tumor response, changes in tumor volume and vascularity, and anti-AMG 780 antibody formation. Results: Forty-five patients were enrolled across nine dose cohorts. Three patients had DLTs (0.6, 10, and 30 mg/kg), none of which prevented dose escalation. At 30 mg/kg, no maximumtolerated dose was reached. Pharmacokinetics of AMG 780 were dose proportional; median terminal elimination half-life was 8 to 13 days. No anti-AMG 780 antibodies were detected. At week 5, 6/16 evaluable patients had a >20% decrease in volume transfer constant (Ktrans), suggesting reduced capillary blood flow/permeability. The most frequent AEs were hypoalbuminemia (33%), peripheral edema (29%), decreased appetite (27%), and fatigue (27%). Among 35 evaluable patients, none had an objective response; eight achieved stable disease. Conclusions: AMG 780 could be administered at doses up to 30 mg/kg Q2W in patients with advanced solid tumors. AMG 780 treatment resulted in tumor vascular effects in some patients. AEs were in line with toxicity associated with antiangiopoietin treatment.Copyright © 2016 American Association for Cancer Research.

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Dowlati, A., Vlahovic, G., Natale, R. B., Rasmussen, E., Singh, I., Hwang, Y. C., … Pickett, C. A. (2016). A phase I, first-in-human study of AMG 780, an angiopoietin-1 and-2 inhibitor, in patients with advanced solid tumors. In Clinical Cancer Research (Vol. 22, pp. 4574–4584). American Association for Cancer Research Inc. https://doi.org/10.1158/1078-0432.CCR-15-2145

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