Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and under controlled environmental conditions. Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance.
Morozova, T. V., Anholt, R. R. H., & Mackay, T. F. C. (2007). Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. Genome Biology, 8(10). https://doi.org/10.1186/gb-2007-8-10-r231