In this issue of Molecular Cell, Zhang et al. (2011) report the structure of the p110β/p85β complex and identify a new inhibitory interaction between p110β and the p85 cSH2 domain. The tighter control of p110β mediated by this interaction appears to be balanced by the disruption of inhibitory contacts with the p85 iSH2 domain (Dbouk et al., 2010). © 2011 Elsevier Inc.
Vogt, P. K. (2011, March 4). PI3K p110β: More Tightly Controlled or Constitutively Active? Molecular Cell. https://doi.org/10.1016/j.molcel.2011.02.017