PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

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Abstract

Glycoprotein B (gB) is one of the essential components for infection by herpes simplex virus-1 (HSV-1). Although several cellular receptors that associate with glycoprotein D (gD), such as herpes virus entry mediator (HVEM) and Nectin-1, have been identified, specific molecules that mediate HSV-1 infection by associating with gB have not been elucidated. Here, we found that paired immunoglobulin-like type 2 receptor (PILR) α associates with gB, and cells transduced with PILRα become susceptible to HSV-1 infection. Furthermore, HSV-1 infection of human primary cells expressing both HVEM and PILRα was blocked by either anti-PILRα or anti-HVEM antibody. Our results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRα plays an important role in HSV-1 infection as a coreceptor that associates with gB. These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection. © 2008 Elsevier Inc. All rights reserved.

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Satoh, T., Arii, J., Suenaga, T., Wang, J., Kogure, A., Uehori, J., … Arase, H. (2008). PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B. Cell, 132(6), 935–944. https://doi.org/10.1016/j.cell.2008.01.043

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