Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity

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Abstract

Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pim genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth. © 2005 Elsevier Inc. All rights reserved.

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Rainio, E. M., Ahlfors, H., Carter, K. L., Ruuska, M., Matikainen, S., Kieff, E., & Koskinen, P. J. (2005). Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity. Virology, 333(2), 201–206. https://doi.org/10.1016/j.virol.2005.01.001

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