Women who are carrying a trisomy 13 fetus are prone to have an abnormal placenta as well as to develop preeclampsia in the second and third trimesters. This article provides a comprehensive review of placental abnormalities, such as small placental volume, reduced placental vascularization, a partial molar appearance of the placenta and placental mesenchymal dysplasia, and preeclampsia associated with trisomy 13 pregnancies. The candidate preeclampsia-causing genes on chromosome 13, such as sFlt1, COL4A2 and periostin, are discussed.
Chen, C. P. (2009). Placental abnormalities and preeclampsla in trisomy 13 pregnancies. Taiwanese Journal of Obstetrics and Gynecology. Elsevier (Singapore) Pte Ltd. https://doi.org/10.1016/S1028-4559(09)60028-0