How the Zika virus (ZIKV) accesses the embryo remains unknown. In this issue, Quicke et al. (2016) use an in vitro model of the human placenta to show that placental macrophages are more permissive to ZIKV infection than trophoblasts, which may be refractory to infection (Bayer et al., 2016).
Adibi, J. J., Zhao, Y., Cartus, A. R., Gupta, P., & Davidson, L. A. (2016, July 13). Placental Mechanics in the Zika-Microcephaly Relationship. Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2016.06.013