Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women

  • M.A. W
  • G.B. W
  • I.B. K
  • et al.
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Background: We examined the relationship between maternal plasma lipoprotein and antioxidant status with risk of preeclampsia among women delivering at Harare Maternity Hospital, Zimbabwe. Methods: One hundred seventy-three pregnant women with preeclampsia and 186 controls were included in a case-control study. Maternal plasma total cholesterol, high-density lipoprotein (HDL), and total triglycerides were measured using enzymatic methods. Plasma carotenoids (α-carotene, β-carotene, lycopene, lutein, β-cryptoxanthin, zeaxanthin), retinol, and tocopherols (α-tocopherol and γ-tocopherol) were determined using high performance liquid chromatography. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Preeclampsia risk increased with successively higher quartiles of plasma triglyceride (OR: 1.00, 1.70, 2.00, 5.26, with the lowest quartile as referent; P for trend < .001). We noted an inverse association between preeclampsia risk and HDL cholesterol concentrations (OR: 1.00, 0.87, 0.66, 0.68, with the first quartile as the referent group; P for trend = .169), although the trend was not statistically significant. After adjusting for confounders, we noted decreases in preeclampsia risk with increasing concentrations of α-carotene, β-carotene, β-cryptoxanthin, lutein, and zeaxanthin, respectively. Women with β-carotene concentrations in the highest quartile, as compared with those in the lowest quartile experienced a 50% decreased risk of preeclampsia (OR = 0.50, 95% CI 0.25-1.00). There was no clear pattern of preeclampsia risk with lycopene concentrations or with concentrations of γ- and α-tocopherol. Conclusions: Our results are consistent with some, although not all, previous reports. Prospective studies are needed to determine the temporal relationship between observed alterations in lipid and antioxidant concentrations in preeclamptic pregnancies. © 2003 American Journal of Hypertension, Ltd.




M.A., W., G.B., W., I.B., K., L., J., & K., M. (2003). Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women. American Journal of Hypertension. M.A. Williams, Swedish Medical Center, Center for Perinatal Studies, 747 Broadway, Seattle, WA 98122, United States. E-mail: Elsevier Inc. Retrieved from

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