Polyphenol derivatives - Potential regulators of neutrophil activity

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The study provides new information on the effect of natural polyphenols (derivatives of stilbene - resveratrol, pterostilbene, pinosylvin and piceatannol and derivatives of ferulic acid - curcumin, N-feruloylserotonin) on the activity of human neutrophils in influencing oxidative burst. All the polyphenols tested were found to reduce markedly the production of reactive oxygen species released by human neutrophils on extra-and intracellular levels as well as in cell free system. Moreover, pinosylvin, curcumin, N-feruloylserotonin and resveratrol decreased protein kinase C activity involved in neutrophil signalling and reactive oxygen species production. Our results suggest that due to their anti-neutrophil activity, the polyphenols tested might be attractive candidates in therapeutic development. Copyright ? 2012 SETOX & IEPT, SASc.




Drábiková, K., Perečko, T., Nosál, R., Harmatha, J., Šmidrkal, J., & Jančinová, V. (2012). Polyphenol derivatives - Potential regulators of neutrophil activity. Interdisciplinary Toxicology. https://doi.org/10.2478/v10102-012-0011-8

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