Polyphenols from Ginkgo biloba

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Abstract

By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted to acidic depolymerization in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D-and reverse 2D-NMR (HSQC, HMBC) spectra of their peracetylated derivatives, MALDI-TOF-MS and CD-spectroscopy. The observations resulting from the degradation with phloroglucinol were confirmed by (13)C-NMR spectroscopy of the polymer. The mean molecular weight of the polymeric fraction was estimated to be 9â10 flavan-3-ol-units.

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Qa’dan, F., Nahrstedt, A., Schmidt, M., & Mansoor, K. (2010). Polyphenols from Ginkgo biloba. Scientia Pharmaceutica, 78(4), 897–907. https://doi.org/10.3797/scipharm.1003-19

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