Posaconazole as rescue therapy in African histoplasmosis

11Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

African histoplasmosis is a granulomatous mycosis caused by Histoplasma capsulatum var. duboisii. Treatment is usually extrapolated from guidelines for classical histoplasmosis, and includes 2-4 weeks of amphotericin B followed by a step-down maintenance therapy with itraconazole. Pediatric usage of posaconazole, an oral second-generation azole, remains off-label, but recent surveys show that it is safe and well tolerated in children. We report a case of disseminated African histoplasmosis in a 12-year-old boy from Guinea-Bissau. Therapy with amphotericin B and itraconazole led to a progressive clinical deterioration. A dramatic and lasting improvement was observed using posaconazole. He completed 12 months of therapy. No relapse was noted during or 3 months after treatment. We report that posaconazole may be a safe and efficacious drug in the salvage management of disseminated AH, either in patients with disease refractory to conventional anti-fungal therapy, or in patients whose serious adverse effects of first-line drugs preclude its use. © 2013 Elsevier Editora Ltda.

Cite

CITATION STYLE

APA

Gonçalves, D., Ferraz, C., & Vaz, L. (2013). Posaconazole as rescue therapy in African histoplasmosis. Brazilian Journal of Infectious Diseases, 17(1), 102–105. https://doi.org/10.1016/j.bjid.2012.06.027

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free