Post-transcriptional control in the male germ line

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Abstract

Post-transcriptional mechanisms play an important role in the biology of germ cells, where they control key developmental decisions in cell division, differentiation and death. Because these post-transcriptional controls are cell-type-specific, and often utilize germ-cell-specific RNA-binding proteins, they provide useful diagnostic markers for male infertility and testicular cancer. Investigation of the genetics of male infertility in men and model organism suggests that disruption of post-transcriptional control mechanisms can cause specific germ cell pathologies, and these studies point to future possible therapeutic routes for restoring spermatogenesis.

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Ehrmann, I., & Elliott, D. J. (2005). Post-transcriptional control in the male germ line. Reproductive BioMedicine Online, 10(1), 55–63. https://doi.org/10.1016/S1472-6483(10)60804-8

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