The potential of dendrimer in delivery of therapeutics for dentistry

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Abstract

Dendrimers are hyperbranched nanoparticle structures along with its surface modifications can to be used in dental biomaterials for biomimetic remineralisation of enamel and dentin. The review highlights the therapeutic applications of dendrimers in the field of dentistry. It addresses the possible mechanisms of enhancement of mechanical properties of adhesives and resins structure. Dendrimers due to its unique construction of possessing inner hydrophobic and outer hydrophilic structure can act as drug carrier for delivery of antimicrobial drugs for treatment of periodontal diseases and at peripheral dental implant areas. Dendrimers due to its hyperbranched structures can provides a unique drug delivery vehicle for delivery of a drug at specific site for sustained release for therapeutic effects. Thus, dendrimers can be one of the most important constituents which can be incorporated in dental biomaterials for better outcomes in dentistry.

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Bapat, R. A., Dharmadhikari, S., Chaubal, T. V., Amin, M. C. I. M., Bapat, P., Gorain, B., … Kesharwani, P. (2019). The potential of dendrimer in delivery of therapeutics for dentistry. Heliyon, 5(10). https://doi.org/10.1016/j.heliyon.2019.e02544

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