Potential interest of a new absorbable collagen membrane in the prevention of adhesions in paediatric cardiac surgery: A feasibility study

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Abstract

Background Open-heart surgery can result in adhesions, which can complicate resternotomy. Aims To document the occurrence of adhesions after the use of a new collagen membrane; to evaluate its tolerability; and to compare surgical parameters with control patients. Methods Paediatric patients who underwent cardiac surgery with the collagen membrane (Cova™ CARD; Biom'up, Saint Priest, France) were analysed retrospectively for levels of adhesion and tolerability. The times of dissection and intervention and the transfusion of packed red blood cells and haemostatic products were compared to a historic cohort who did not receive an anti-adhesion device. Results From January 2010 to December 2011, 36 patients received a collagen membrane. Nineteen re-interventions were performed, after a mean of 169 days. No grade 3 adhesions were observed and no tolerability problems were reported. During re-interventions after more than 30 days, the propensity score-adjusted durations of dissection and the total process for patients with and without a collagen membrane were 32 vs 41 minutes and 151 vs 182 minutes, respectively (not significant). The mean quantities of red blood cells and biological glue administered in the two groups were 98 vs 139 mL and 1.2 vs 0.5 mL, respectively (not significant). Conclusions This feasibility study shows the potential use of the new membrane in paediatric patients, both in terms of prevention from severe adherence and tolerability. This is the first study of this membrane in humans. A prospective, controlled study is necessary to provide strong evidence of its efficiency. © 2013 Published by Elsevier Masson SAS.

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Armoiry, X., Viprey, M., Constant, H., Aulagner, G., Roux, A. S., Huot, L., … Henaine, R. (2013). Potential interest of a new absorbable collagen membrane in the prevention of adhesions in paediatric cardiac surgery: A feasibility study. Archives of Cardiovascular Diseases, 106(8–9), 433–439. https://doi.org/10.1016/j.acvd.2013.05.003

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