PP-090 Hepatitis B, C and D viruses in Tajikistan

  • Abdusamad D
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Abstract

Aim: To study was to investigate the genotypic prevalence and clinical significance of HCV, HBV, and/or HDV among chronic hepatitis patients with and without liver cirrhosis and/or HCC in Tajikistan. Methods: Sera were obtained from 124 consecutive cases of chronic liver diseases. Patients in this study were classified into two clinical groups: (i) chronic hepatitis and (ii) liver cirrhosis. Results: Genotypes of HBV, HCV, and HDV were determined by genetic sequencing. The overall prevalence of anti-HCV, HCV core antigen (HCVcAg) and HBsAg was 46{%} (57/124) and 41.1{%} (51/124), respectively. Co-infection of HCV/HBV, HBV/HDV, and HCV/HBV/HDV was found in 4.8{%} (6/124), 11.2{%} (12/124), and 0.8{%} (1/124) of cases, respectively. HDV genotype 1 was found in 19.6{%} (10/51) of HBsAgpositive patients. The HBV/HDV co-infection was relatively high in group 2 compared with group 1 (15{%} vs. 7.1{%}). HCV/1b was detected in 84.6{%} (44/52) of HCV RNA-positive patients, followed by 3a (7.6{%}), 2a (5.7{%}), and 2c (1.9{%}). HBV/D was detected in 94.1{%} (48/51) of HBsAg-positive patients, followed by HBV/A [5.8{%} (3/51)]. T1762/A1764 double mutation was associated with liver cirrhosis in HBVinfected patients (P = 0.0004). Conclusion: Among HBV-infected patients, the T1762/A1764 mutation was associated with liver cirrhosis.

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Abdusamad, D. (2011). PP-090 Hepatitis B, C and D viruses in Tajikistan. International Journal of Infectious Diseases, 15, S70. https://doi.org/10.1016/s1201-9712(11)60242-7

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